This race is one of the most open opportunity races out there for different boats to have a chance at winning. Like A cats with spinnakers etc. The race is also about the first boat to finish. Because of that, the format was changed to give all a chance to be first across the finish line by using the reverse start. That said, the most disadvantaged group is the monohull cruisers. They have real issues making the math work. Meaning hull speed over the distance needed to finish in, given the time factored by available wind. Next is the monohull, then followed by a generic catamaran, to "fast" cat, those being newer design with power to weight ratios very high, like the M20's. Finally to the big RC boats.
I sail a big RC boat, and for that reason. Got very tired of getting smoked by them on my Prindle 19 with spinnaker. Now that I am on the darkside, it is not as easy as one might think to win.

That said the wind is so unpredictable in this race, that it really does equalize the fleet (at least as much as you can expect). As an example 2 years ago it was won by a Monohull, one of the big scows. During that race, we being an RC 27, with-in 1 mile of the start and we were jibing back and forth across the river with the RC 30. We were even with them and we went to one side of the river, they went to the other. We hit a hole in the light air they didn't. We sat in that no wind hole until 2:30 in the afternoon, still within sight of the start line.
It is this fluky wind that gives all boats the best chance. As John mentioned earlier, if there is real wind all day, the big cat will likely win. However that "real wind all day" only comes around once every 10 or 15 years. So it is definately a catamaran's perfect race and wide open.
Also the Club does its best to make this as easy as possible for the racer.