Banjo music is right. The South lives on in this part of Florida. And as for the Swannee, I've done this stretch in a small john boat. The gators here are serious. There are two kinds, big and bigger. I had my dog in the boat (gators favorite food, the dog, not the boat).
This part of the coast has no distinct beach, only a slow transition from mud and mangrove swamp to shallow Gulf. If you've seen the old movie Africian Queen you get the idea.
This part of Florida is very unique, from Cedar Key to St. Marks. Very remote but worth a visit.
I have done parts of this on my Wave and in kayaks.
I wouldn't worry much about gators or snakes. It is the No-see-ums that will take you down in a hurry. They are usually not out over the water, but thrive around boat ramps, mangroves and beaches. They come out in force just before dusk.